Head of Biochemical and Cellular Engineering

June 7

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Lyterian Therapeutics

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Co-opting physiologically relevant protein homeostatic mechanisms for treating disease

Biotechnology • Pharmaceuticals

11 - 50

Description

• As Head of Biochemical & Cellular Engineering, you will be responsible for leading the team designing biochemical assays relevant to our protein degradation drug discovery platform and programs • You will manage research scientists and external partners, including contract research organizations (CROs) to develop appropriate strategies and screening cascades to drive small molecules' lead optimization • By collaborating closely with medicinal chemists, protein biochemists, biophysicists, bioinformaticians, and molecular biologists, you will uncover fundamental biology behind induced protein degradation

Requirements

• PhD in Biochemistry, Pharmacology, Cell Biology, Biology, Chemical Biology, or related discipline with 10+ years of relevant postdoctoral or industrial experience • Experience successfully initiating and executing high-quality biochemical and cell-based assays in medium/high-throughput formats for drug discovery • Strength in experimental design, assay development, execution, and expertise in several assay platforms to analyze target engagement and degradation (such as HTRF, luminescence, NanoBRET, CETSA, High Content Imaging, flow cytometry) • Research experience with characterization of protein modification and turnover, and cellular mechanism of action studies. • In-depth knowledge of modern in vitro pharmacology approaches and principles that contribute to successful delivery of candidate drugs • Ability to independently define key scientific questions and design rigorous experiments in collaboration with internal and external partners, including CROs • Familiar with data analysis software and databases for the handling of large datasets • Knowledge of protein degradation mechanisms and in particular the biochemistry of ubiquitin ligases is a plus • Excellent verbal and written communication skills, including strong formal presentation skills and the ability to communicate complex scientific information in an understandable manner • Evidence of scientific excellence and impact as illustrated by scientific publications and presentations • Initiative and boldness to dive into a fast-paced new startup

Benefits

• Lead the scientific direction and operation of the Biochemical and Cellular Engineering Group and promote innovative science through collaboration and teamwork • Contribute to multiple drug discovery projects via the design, implementation and interpretation of robust biochemical and cell-based assays for lead optimization, HTS, and mechanism of action studies • Support projects and project teams by implementing robust in vitro cascades to deliver drug candidates • Identify, initiate, and manage collaborations with external collaborators and CROs, including assay development, execution, quality control (QC), and handling of data • Employ rigorous data analysis techniques and ensure pharmacological data generated by the team is reviewed and reported in appropriate format to enable ease of access in appropriate databases • Serve as the scientific leader and subject matter expert (SME) in biochemical and cellular engineering on multiple project teams • Contribute to technical reports to support program reviews, patents, publications and IND submissions • Stay up-to-date with emerging scientific literature • Collaborate and communicate across a diverse scientific team to successfully progress Lyterian goals