Sr. Research Associate, Discovery Biology
3 days ago
🏢 In-office - Bay Area
Description
• Contribute to the design of protein production strategies, including construct designs and purification schemes to generate protein reagents for use in biochemical and biophysical assays and structural characterization of protein complexes • Produce high-quality protein for various in vitro assays and assist with troubleshooting and optimizing expression/purification protocols • Assist with identifying and implementing state-of-the-art techniques and experimental approaches in protein sciences • Perform QC analysis by applying appropriate analytical techniques to ensure the final products meet the required criteria for in vitro assays • Assist with overseeing protein expression/purification efforts at external CROs • Work closely with project teams for timely delivery of protein reagents • Effectively communicate with colleagues and stakeholders; provide updates to project teams and present results at project team and group meetings • Maintain a clear and detailed laboratory notebook to document all experiments and findings • Comply with best laboratory safety practices
Requirements
• B.S. or M.S. in Biochemistry, Structural Biology, Biophysics, or a related discipline with at least 3 years of hands-on experience in an industry setting • Broad experience in expressing recombinant proteins in various expression systems and modern molecular cloning techniques • Extensive hands-on experience in protein purification using various chromatographic methods with proficiency in the AKTA FPLC systems • Experience in using analytical/biophysical techniques (HPLC, DLS, DSF, etc.) to assess the stability, solubility, and oligomerization status of proteins • Experience in structural biology (X-ray crystallography, NMR, Cryo-EM) and methods for isolating and characterizing protein complexes highly desired • Excellent communication, organization, and technical writing skills • Strong problem-solving skills and ability to learn new skills • Excellent communication, organization, and technical writing skills
Benefits
• Patient Days, where we hear from individuals living with the conditions we impact throughout the year and learn how we can improve our efforts • A culture inspired by our values: put patients first, think independently, be radically transparent, every minute counts, and let the science speak • An unyielding commitment to always putting patients first. Learn more about how we do this here • A de-centralized model that enables our program teams to focus on advancing science and helping patients. Our affiliate structure is designed to eliminate bureaucracy and put decision-making power in the hands of those closest to the science • A place where you own the vision – both for your program and your own career path • A collaborative, fast-paced, data-driven environment where we inspire ourselves and each other to always perform at the top of our game • Access to learning and development resources to help you get in the best professional shape of your life • Robust and market-competitive compensation & benefits package (Base, Performance Bonus, Equity, health, welfare & retirement programs) • Flexible PTO • Rapid career advancement for strong performers • Potential ability to work on multiple GondolaBio programs across multiple therapeutic areas over time • Partnerships with leading institutions • Commitment to Diversity, Equity & Inclusion
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