Senior Research Associate I, Drug Discovery Formulation Science
3 days ago
🏢 In-office - San Francisco
Description
• Conduct activities related to test article formulation to support drug discovery programs • Execute experiments for the formulation and QC of oral and parenteral vehicles for in vivo evaluation of novel lead materials. • Prepare and deliver accurate formulation of test articles to achieve experimental goals. • Work closely with experts in medicinal chemistry, DMPK, pharmacology, and technical operations to generate key data that drive understanding of ADMET properties and test article pharmacology. • Partner with Technical Operations and CMC teams to develop prototype formulations and processes for non-GLP pre-clinical studies in advanced research programs. • Operate state-of-the-art analytical instruments, such as Agilent HPLC 1260, waters LCMS, PLM, and Rigaku Miniflex XRPD. • Track formulation activities under tight timelines, ensuring cross-functional collaboration and accountability.
Requirements
• Master's with 2+ years, or Bachelor’s with 5+ years of relevant experience in an academic, biotech, or pharmaceutical industry • Degree in Pharmaceutics, Pharmaceutical Sciences, Chemistry, Analytical Chemistry, Biochemistry, Chemical Engineering, or related discipline • Proven experience in developing and optimizing oral and/or parenteral formulations of small molecules for the characterization of ADMET properties or in vivo pharmacology • Hands-on experience with HPLC analysis, stability testing, and physicochemical property determination. Familiarity with solid form characterization techniques, including PLM, TGA, DSC, XRPD, and Dissolution preferred. • Strong experimental design skills for various dose formulations, along with expertise in developing methods for drug materials with low solubility. • Exceptional attention to details and experience in protocol writing experience for accurately recording experimental parameters and procedures. • Excellent communication, organization, time management, and documentation skills. Ability to work both independently and collaboratively.
Benefits
• Competitive medical, dental, and vision insurance • Mental health offerings • Equity incentive plan • 401(k) program with employer match • Generous holiday and PTO policy
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